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Rejuve.AI Joins the Joyspan Experiment at Frontier Tower


As 2025 draws to a close, Rejuve.AI is entering one of its most pivotal moments yet. The momentum building during these final weeks of the year is setting the stage for a transformative 2026, with new scientific pilots, partnerships and decentralized research initiatives coming to life. Today we are excited to share that we are participating in an early scientific pilot hosted inside Frontier Tower, an environment built for real-world experimentation in culture, wellbeing and collective experience. 


The study, called the JoyScore Experiment, explores joy, synchrony and human connection as measurable components of health. It examines how shared movement, curated atmosphere and emotional states interact with physiology and day-to-day lived experience, while also testing an early model of decentralized trials through participant-owned data and tokenized contribution.


What Is Frontier Tower? 


On the outside, Frontier Tower is a 16-story building at 995 Market Street in downtown San Francisco [1]. Step inside and it feels more like entering a portal from the present into a world that offers a glimpse into a future shaped by frontier technologies advancing alongside a new era of human flourishing.


Each floor follows its own frontier theme, including longevity, AI, crypto, biotech, neurotech, human flourishing, arts and music. Founders, researchers and creators live, work and host gatherings across these levels, turning the tower into a living laboratory where new forms of community and innovation take shape.


This identity was shaped in June 2025, when Viva City spearheaded a vertical village pop-up that activated several floors as a temporary micro-community combining residency, coworking, cultural programming and collaborative research [2], [3]. Since then, Frontier Tower has hosted speakers, founders and teams connected to companies and research groups such as DeepOrigin, NVIDIA, Perplexity, the Foresight Institute, the Ethereum Foundation, EthGlobal, Singularity University, Altos Labs and UC Berkeley, along with pitch events featuring venture firms and angel investors. These activations demonstrate that the tower is a functioning hub for people working at the leading edge of science, technology and human wellbeing.


This mix of intentional design, themed floors and real-world community dynamics creates an ideal environment for the JoyScore Experiment [4]. It provides the structure needed for carefully run sessions while preserving the natural complexity of human interaction, movement and co-regulation in a shared space.


About the JoyScore Experiment


The JoyScore Experiment is led by Tina Woods, founder of Collider Health, executive director of the International Institute of Longevity and a leading advocate for the Human Exposome Project [5]. She is also the founder of Longevity Rave, a cultural movement that uses sober dance events to show how music, connection and joy can support healthy longevity [6].


The experiment builds on growing research in synchrony, collective music engagement and embodied health. Similar ideas are now reaching mainstream attention through events like Bryan Johnson’s Don’t Die Summits, which start the day with morning raves that combine movement, metrics and community [7]. In this study, those concepts are translated into a structured scientific protocol.


On December 4th & 9th Participants take part in two sessions at Frontier Tower. One session serves as a structured control. The second includes synchrony-oriented elements such as coordinated movement, curated tempo arcs and sensory settings aligned with entrainment science [8]. The study draws from evidence showing that synchronized dance increases bonding and pain tolerance, supports neuroplasticity and enhances emotional wellbeing.


Data is collected through EEG, wearable motion sensors, autonomic signals, microsamples for biological analysis, ecological momentary assessments (EMA) and environmental parameters such as sound, light and crowd density. Rather than isolating a single variable, the experiment treats each session as a dense exposome moment, capturing how multiple environmental, emotional and social layers shape physiology and experience.


All methods and appropriately de-identified outputs will align with open science principles and support the broader Human Exposome Project.


Exposome-based design


The experiment is grounded in the exposome: the totality of environmental, behavioural and social exposures that shape health across a lifetime [9]. Rather than isolating a single variable, the JoyScore protocol treats the event as a dense exposome “moment” and captures how multiple layers of experience interact with biology, mood and daily life.


Frontier Tower is ideal for this, because the space can be shaped very precisely while still feeling like a real community gathering. That balance between control and authenticity is essential for next-generation exposome research.


A collaborative effort


The JoyScore Experiment brings together a set of aligned partners, including:


  • Longevity Rave, providing the cultural and scientific framework for sober longevity raves and synchrony-based events.

  • AWEAR, supplying ear-based EEG wearables to capture brain and autonomic signals in real-world settings [10].

  • Bleo, contributing tools for tracking stress, recovery and adaptive capacity [11].

  • Humanity, a healthspan app focused on biological age and lifestyle change [12].

  • OpenCures, enabling advanced biomarker analysis and citizen-science infrastructure [13].

  • The Sound Nutritionist, shaping soundscapes and sonic interventions that support emotional regulation and connection [14].

  • Rejuve.AI, providing the digital infrastructure for exposome and EMA tracking, participant data sovereignty and decentralized trial workflows [15].


Data collected includes:


  • Ear-based EEG

  • Movement patterns from IMUs

  • Heart and autonomic signals

  • Brief surveys collected through EMA (Ecological Momentary Assessment)

  • Environmental and sensory parameters

  • Microsamples (blood) for biological analysis

  • Functional and physiological biomarkers



Why Joy Is a Missing Metric in Healthspan Science


Healthspan science has made major progress in tracking sleep, metabolic health, inflammation, physical activity and biological age. Yet joy, play, connection and meaning are still poorly measured, even though they strongly influence resilience, adherence and long-term wellbeing.


The idea of “joyspan” has been shaped by contributors across the longevity field. Gerontologist Dr Kerry Burnight uses the term to frame joy and purpose as core elements of healthy aging [16]. Exceptional Ventures applied the same concept in their work with founders, emphasizing that wellbeing and connection are as essential as lifespan itself [17]. Both perspectives reinforce a shared insight: extended life must also be a joyful one.


Across science, investing and culture, joyspan is converging on the same idea: longevity is not meaningful unless people actually enjoy the lives they are extending. Enjoyment of life shapes how people engage with protocols, communities and cities that aim to support long, healthy lives. It also affects how society will respond if emerging therapies push life expectancy toward 120 or 150 years. A future of extended healthspan without joy, belonging and purpose would not be a success.


The JoyScore Experiment contributes by trying to quantify joy as a healthspan biomarker. It looks at synchrony, emotional state, collective movement, neural patterns and subjective reports together, building a richer picture of how joy arises in real environments and how it may support recovery, resilience and long-term health.



Rejuve.AI’s Role in the Experiment 


Rejuve.AI is providing the daily EMA and exposome tracking system that supports the study’s mixed-method design. Participants use the Rejuve app to log sleep quality, mood, energy, stress, social connectedness, lifestyle inputs and overall daily wellbeing. These entries help contextualize the physiological and neural signals collected throughout the study window.

These Ecological Momentary Assessment entries turn the event from a single high-energy night into a continuous dataset that spans days. They help researchers interpret physiological and neural data in the context of how people are actually living, working and recovering before and after each session.


The pilot also tests the foundations of Rejuve’s decentralized trial framework:


  • Participants receive RJV tokens as recognition for their contribution.

  • In future releases, they will be able to connect this participation to their DataNFT, preserving a verifiable record of their involvement in the study [18].

  • The resulting dataset can feed into Rejuve’s International Longevity Research Database (IRLDB), helping train models and generate insights that benefit the wider community [19].


This creates a model in which individuals can participate in research, support open science and retain ownership of their contributions. Early use cases bring Rejuve’s IRLDB platform to life with real-world data, placing it at the epicenter of decentralized science and emerging trial models that can accelerate and scale longevity insights. Over time, this can help make health-extending protocols more accessible to more people rather than remaining limited to the ultra-wealthy.


Advancing DeSci Through Real-World Research Environments


Frontier Tower represents a new type of research environment. It brings scientific experimentation into dynamic cultural space while maintaining enough control to generate high-quality data. This hybrid model supports exposome research, decentralized trials and participant-owned data.


By hosting this study inside a vibrant cultural environment rather than a traditional laboratory, the collaborators demonstrate how scientific research can evolve toward more naturalistic, inclusive and context-rich settings. Frontier Tower points to a new kind of research infrastructure that blends environmental control with real-world experience.


The JoyScore Experiment shows how decentralized science (aka DeSci) [20], exposome research and participant-owned data can work together. It supports transparent scientific outputs, community participation and methods that can scale across locations and populations.


Rejuve.AI is contributing the digital infrastructure that organizes time-stamped exposome data, supports decentralized participation and connects individuals to the broader DeSci ecosystem. As the study progresses, we will continue to share insights from this early and promising collaboration.


Running the JoyScore Experiment inside Frontier Tower reveals what DeSci can look like when it moves fully into the real world. It demonstrates decentralized trials that recognize participant contributions, exposome-aware design that views environment and culture as essential variables, and open collaborative infrastructure uniting organizations such as Longevity Rave, Rejuve.AI, AWEAR, Bleo, Humanity, OpenCures and The Sound Nutritionist.


As the study unfolds, Rejuve.AI will continue to share learnings from this collaboration. We are excited to help turn joy, synchrony and collective experience into measurable, actionable components of healthspan science while building the decentralized tools that allow more people and places to participate.



References


[1] Frontier Tower. (2025). Frontier Tower. https://frontiertower.io

[2] Viva City. (2025). Frontier Tower Pop-Up Village. https://viva.city/frontier-tower

[4] Longevity Rave. (2025). The JoyScore Experiment. https://www.longevityrave.world/the-joyscore-experiment

[5] Human Exposome Project. (2023). Human Exposome Project. https://humanexposomeproject.com

[6] Longevity Rave. (n.d.). Longevity Rave. https://www.longevityrave.world

[7] Men’s Health. (2024). Inside Bryan Johnson’s Don’t Die Summit: The billionaire biohacker’s anti-death movement explained. https://www.menshealth.com/health/a63664080/bryan-johnson-dont-die-summit/

[8] Phillips-Silver, J., Aktipis, C. A., & Bryant, G. A. (2010). The ecology of entrainment: Foundations of coordinated rhythmic movement. Music Perception: An Interdisciplinary Journal, 28(1), 3–14. https://doi.org/10.1525/mp.2010.28.1.3

[9] Woods, T., Palmarini, N., Corner, L., & Siow, R. (2025). Cities, communities and clinics can be testbeds for human exposome and aging research. Nature Medicine, 31(4), 1066–1068. https://doi.org/10.1038/s41591-025-03519-8 

[10] AWEAR Technologies. (2025). AWEAR. https://awear.us  

[11] Bleo Health. (2025). Bleo. https://bleo.ai 

[12] Humanity Inc. (2025). Humanity. https://humanity.health

[13] OpenCures. (2025). OpenCures. https://opencures.org

[14] The Sound Nutritionist. (2025). The Sound Nutritionist. https://thesoundnutritionist.com 

[16] Burnight, K. (2025). Joyspan: The art and science of thriving in life’s second half. Aster. https://drkerryburnight.com/ 

[17] Exceptional Ventures. (n.d.). Exceptional Ventures. https://exceptional.ventures/ 

[18] Rejuve.AI. (2023, July 26). Rejuve Data NFT: Enabling health data sovereignty with the Data NFT (dNFT). Rejuve.AI. https://www.rejuve.ai/post/rejuve-data-nft

[19] Rejuve.AI. (2025, September 12). Rejuve.AI receives IRB approval to decentralize longevity research. Rejuve.AI. https://www.rejuve.ai/post/irb-review

[20] Onchain.org. (2024). What is decentralized science (DeSci)? https://onchain.org/magazine/what-is-decentralized-science-desci/


 
 
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